IDSwiss AccGene NameAliasDescription
3553P01584IL1BIL-1; IL1F2; IL1-BETA; IL-1betainterleukin 1, beta

Other aliasesIL1; IL1B; IL-1; IL 1; IL 1B; IL1F2; IL-1B; IL1-b; IL 1 B; IL1F-2; IL1F 2; IL-1 b; IL 1,b; IL 1- b; IL1beta; IL 1, b; IL 1 F-2; IL 1 F 2; IL-1beta; IL1-BETA; IL 1,beta; IL-1 beta; Catabolin; IL 1 beta; IL 1- BETA; IL 1, beta; interleukin-1; interleukin 1; interleukin-1B; interleukin 1B; interleukin 1 B; interleukin-1 b; interleukin 1,b; interleukin 1- b; interleukin 1, b; interleukin 1 F-2; interleukin 1 F 2; interleukin-1beta; interleukin 1,beta; interleukin 1 beta; interleukin-1 beta; interleukin 1- BETA; interleukin 1, beta; Interleukin-1beta precursor; Interleukin-1 beta precursor

FunctionThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.


Gene OntologyGO:0008283 cell proliferation
GO:0007267 cell-cell signaling
GO:0006915 apoptosis
GO:0005149 interleukin-1 receptor binding
GO:0000074 regulation of progression through cell cycle
GO:0019735 antimicrobial humoral response (sensu Vertebrata)
GO:0008285 negative regulation of cell proliferation
GO:0006954 inflammatory response
GO:0004871 signal transducer activity
GO:0001660 fever
GO:0007165 signal transduction
GO:0005615 extracellular space

Database cross references



Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
A2Min vitro;in vivo
MMP2in vitro
CASP1in vitro;in vivo
IL1Bin vitro;in vivo
IL1R1in vitro
IL1R2in vitro
PRTN3in vivo
IL1RAPin vitro
ADRB2in vitro
CASP4in vitro

Interacting Partners (NetPath)IL1R1 [2946959 ] IL1R2 [7878046 ]

Interacting Partner (IntAct)Interaction typeDetection method
IL1R1 direct interaction x-ray

Pathway (NetPath)PubMedRegulationExperiment
IL-116264101,15950496,15464974 UpregulationMicroarray
IL-28038234 UpregulationNon-Microarray
IL-38038234 UpregulationNon-Microarray
IL-512600815 UpregulationMicroarray
TGF-beta Receptor14726474,11267935 DownregulationMicroarray
Wnt14707084 DownregulationMicroarray
TNF-alpha12212969,12754109 UpregulationNon-Microarray

Pathway (KEGG)[MAPK signaling pathway] [Cytokine-cytokine receptor interaction] [Apoptosis] [Toll-like receptor signaling pathway] [Hematopoietic cell lineage] [Type I diabetes mellitus] [Alzheimer's disease]

Pathway (CGAP/BioCarta)[Signal transduction through IL1R ] [IL 5 Signaling Pathway ] [Msp/Ron Receptor Signaling Pathway ] [NFkB activation by Nontypeable Hemophilus influenzae ]

© 2008 National Taiwan Univerisity, Taipei, Taiwan