IDSwiss AccGene NameAliasDescription
2539P11413G6PDG6PD1glucose-6-phosphate dehydrogenase
[more aliases]
FunctionThis gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia.


Gene OntologyGO:0005975 carbohydrate metabolism
GO:0006098 pentose-phosphate shunt
GO:0006010 glucose 6-phosphate utilization
GO:0006006 glucose metabolism
GO:0016491 oxidoreductase activity
GO:0004345 glucose-6-phosphate 1-dehydrogenase activity
GO:0008372 cellular component unknown

Database cross references



Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
G6PDin vitro
SUMO4in vivo

Pathway (NetPath)PubMedRegulationExperiment
TGF-beta Receptor11267935 DownregulationMicroarray

Pathway (KEGG)[Pentose phosphate pathway] [Glutathione metabolism]

© 2008 National Taiwan Univerisity, Taipei, Taiwan