IDSwiss AccGene NameAliasDescription
2185Q14289PTK2BPKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTKPTK2B protein tyrosine kinase 2 beta
[more aliases]
FunctionThis gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0005737 cytoplasm
GO:0006950 response to stress
GO:0005515 protein binding
GO:0006461 protein complex assembly
GO:0008284 positive regulation of cell proliferation
GO:0006915 apoptosis
GO:0005856 cytoskeleton
GO:0000166 nucleotide binding
GO:0007155 cell adhesion
GO:0005524 ATP binding
GO:0006468 protein amino acid phosphorylation
GO:0004871 signal transducer activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0007172 signal complex formation
GO:0007165 signal transduction
GO:0016740 transferase activity

Database cross references

STITCHPTK2B

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
GRB2in vivo
EGFRin vivo
EWSR1in vitro;in vivo
SLC2A1in vivo
FYNin vitro;in vivo
GSNin vitro;in vivo;yeast 2-hybrid
GRIN2Ain vivo
DDEF1in vitro;in vivo;yeast 2-hybrid
JAK2in vivo
JAK1in vitro;in vivo
PRKCDin vivo
CRKin vitro;in vivo
ITGB3in vitro;in vivo
ERBB2in vivo
VAV1in vitro;in vivo
KCNA2in vivo
SNCAin vitro;in vivo
LYNin vivo
PTK2in vitro
PTPN11in vitro;in vivo
LCKin vitro;in vivo
PTPN6in vitro;in vivo
CBLin vivo
MCAMin vitro
ZAP70in vivo
PIK3R1in vivo
MATKin vitro;in vivo
ITGB2in vitro;in vivo
DLG3in vitro;in vivo
TLN1in vivo
SRCin vitro;in vivo
FLT1in vivo
PTPN12in vitro;in vivo
SYKin vivo
SHC1in vitro;in vivo
JAK3in vitro
PTK2Bin vitro;in vivo
CCR5in vivo
PXNin vitro
DLG4in vitro;in vivo
BCAR1in vivo
DDEF2in vitro;in vivo
GNA13in vitro;in vivo
LPXNin vivo
RB1CC1in vitro;in vivo;yeast 2-hybrid
ARHGAP21in vitro;in vivo;yeast 2-hybrid
PITPNM1in vitro;in vivo;yeast 2-hybrid
PITPNM3in vitro;in vivo;yeast 2-hybrid
PITPNM2in vitro;in vivo;yeast 2-hybrid
NPHP1in vitro;in vivo
EFSin vitro
NEDD9in vivo
SORBS2in vitro
IL7Rin vivo
MAP3K4in vitro
STAT3in vitro
PDPK1in vivo
ERBB3in vitro
FGFR3in vitro;in vivo
RASA1in vivo
ARHGAP5in vivo
FGFR2in vitro;in vivo
SH2D3Cin vitro;in vivo
-in vitro
TGFB1I1in vitro;in vivo
DLGAP3in vitro

Interacting Partners (NetPath)GRB2 [9091579 ] PXN [9091579 ] LCK [9257837,9091579 ] FYN [10867021,9091579 ] SH2D3C [12486027 ] JAK3 [9512511 ] PTPN11 [10880513 ] IL7R [10702271 ] JAK1 [10702271 ]

Interacting Partner (IntAct)Interaction typeDetection method
EGFR physical interaction anti bait coip

Pathway (NetPath)PubMedRegulationExperiment
T Cell Receptor10586059 UpregulationNon-Microarray

Pathway (KEGG)[Calcium signaling pathway] [Natural killer cell mediated cytotoxicity] [Leukocyte transendothelial migration] [GnRH signaling pathway]

Pathway (CGAP/BioCarta)[Role of nicotinic acetylcholine receptors in the regulation of apoptosis ] [Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling ] [Bioactive Peptide Induced Signaling Pathway ] [Pertussis toxin-insensitive CCR5 Signaling in Macrophage ] [CXCR4 Signaling Pathway ] [Calcium Signaling by HBx of Hepatitis B virus ] [IL-7 Signal Transduction ] [Ion Channel and Phorbal Esters Signaling Pathway ] [Signaling of Hepatocyte Growth Factor Receptor ] [Ras-Independent pathway in NK cell-mediated cytotoxicity ] [Thrombin signaling and protease-activated receptors ] [Links between Pyk2 and Map Kinases ]


© 2008 National Taiwan Univerisity, Taipei, Taiwan