IDSwiss AccGene NameAliasDescription
1287P29400COL4A5ATS; ASLN; CA54; MGC42377collagen, type IV, alpha 5 (Alport syndrome)
[more aliases]
FunctionThis gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Three transcript variants have been identified for this gene.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0005737 cytoplasm
GO:0005201 extracellular matrix structural constituent
GO:0005581 collagen
GO:0006817 phosphate transport
GO:0005587 collagen type IV

Database cross references

STITCHCOL4A5

Integrated protein interaction and pathway information

Interacting Partners (HPRD)Experiment
APPin vitro
CD93in vitro;in vivo
MMP9in vivo
DCNin vivo
FBLN2in vivo
FN1in vivo
OSMin vitro
SERPINE2in vivo
MATN2in vitro
HABP2in vivo
RNF10yeast 2-hybrid

Interacting Partner (IntAct)Interaction typeDetection method
RNF10 physical interaction two hybrid pooling


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