IDSwiss AccGene NameAliasDescription
11126O95971CD160NK1; BY55; NK28CD160 antigen
[more aliases]
FunctionCD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.

AssociationsTCM-GeneTCM-Gene-Disease

Gene OntologyGO:0008283 cell proliferation
GO:0007166 cell surface receptor linked signal transduction
GO:0030106 MHC class I receptor activity
GO:0046658 anchored to plasma membrane
GO:0006968 cellular defense response
GO:0004872 receptor activity
GO:0005102 receptor binding
GO:0005886 plasma membrane

Database cross references

STITCHCD160

Integrated protein interaction and pathway information

Pathway (NetPath)PubMedRegulationExperiment
TNF-alpha14641910 UpregulationMicroarray


© 2008 National Taiwan Univerisity, Taipei, Taiwan